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Another factor is the shift in gut microbiome composition that GLP-1 receptor agonists can produce

This triple-action mechanism creates a synergistic effect that supersedes the efficacy of mono- and dual-agonists

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Keywords , MASH , GLP-1 receptor agonists , hepatic steatosis , metabolic dysfunction , tirzepatide , semaglutide , survodutide 0 2 INTRODUCTION Metabolic dysfunction-associated steatotic liver disease (MASLD), previously termed nonalcoholic fatty liver disease (NAFLD), has emerged as the predominant hepatic pathology worldwide, impacting roughly twenty-five percent of the adult population [1,2]

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